Bromadiolone vs Bromethalin (Comparative Discussion)

You may notice that rats and mice running everywhere in your house. The situation is highly disturbing. So, you are in dire need of killing them. 

So, which mice killer is better between Bromadiolone vs Bromethalin? 

The effect of bromadiolone is rapid and noticeable within 24 hours. Bromethalin, on the other hand, is less effective and may take up to 2 days to provide a satisfactory result.

Oil-based bromadiolone needs to be sprayed on the affected area. Usually, bromethalin comes in powder form, which you spread on rodent nests.

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Both of these rodenticides possess other factors that must be taken into account. To learn more about them, read the article.   

Bromadiolone vs Bromethalin: Quick Overview

When your bucket mouse trap doesn’t work, you just need to rely on rodenticides. Bromethalin and bromadiolone are two different types of fantastic rodenticides.

Using these, rodent populations can be controlled. Even though they appear to be on the same page, there are some differences between their perspectives.

In this sector, we will get a glance at the common factors of these two rodenticides. Within a short period of time, you will be able to identify both products:  

Feature Bromadiolone  Bromethalin 
Active Ingredients  Bromadiolone  Bromethalin. 
Product formula   Oil-based solution  Powder. 
Effectiveness  Within overnight Within 2 days. 
Bait Attractants  Peanut butter flavor  Palatable.
Dosage  Apply 6 To 7 Blocks Per Placement Give Intervals Of 15 To 30 Feet Use 2 To 8 Blocks Per Placement Give Gap Approximately 15 To 30 Feet.
Resistance  Humidity Resistant Wax Blocks A neurotoxin that is active and non-resistant.
Human and pets Toxicity  Highly Toxic    Highly Toxic.  
Price (4lb) $38.56  $25.11.

Is Bromadiolone The Same As Bromethalin?

Now, it’s time to shed light on the factors in a comprehensive manner. It will help you to know which one would be better for you.  

Factor 1: Active Ingredients

In the Bromadiolone products that we use, the active ingredient is 0.005% of Bromadiolone itself. The rest of the product (99.995%) is made up of inert materials.

bromethalin vs bromadiolone active ingredients


Bromadiolone is an anticoagulant rodenticide. It’s a second-generation single-dose anticoagulant rodenticide. The vitamin K levels in the body are decreased, which disrupts the normal clotting process through Bromadiolone. 

On the other hand, the active ingredient in Bromethalin is 14C-Bromethalin which is a potent neurotoxin. It inhibits the brain’s adenosine Triphosphate production that controls warfarin-resistant rats and mice. 

It is a first-generation rodenticide commonly employed for rodent control in farm animals and poultry houses. Also, Bromethalin, referred to as Alpha-Chlorohydrin is a potent acetylcholinesterase inhibitor. 

Factor 2: Product Formula

Bromadiolone comes in an oil-based solution. You need to spray it on surfaces frequented by rodents, such as behind appliances, inside cabinets, and along walls. 

Bait stations can also be used in infested areas. When compared to other types of bait, these stations have at least one opening for inserting poison blocks or tubes containing liquid bromadiolone.

On the other hand, bromethalin usually comes in small packets filled with powder. You should mix the powder with moist food. That will create an enticing bait for mice or rats.  

Factor 3: Effectiveness 

Both of the rodenticides are effective enough to diminish the center rats and mice.  However, Bromadiolone is highly effective and you can see the results overnight. It takes approximately 20 minutes after ingestion, the body begins breaking down Bromadiolone into a compound called dimethicone. 

On the other hand, you may need to wait 2 days to see any effective results. Because it’s typically less effective. The bromethalin starts reacting with enzymes in the rat’s stomach once it reaches the stomach. Red blood cells are destroyed by these reactions, which results in death.

Factor 4: Bait Attractants

To attract rodents, rodenticides are often formulated as baits. The bait attractants of bromadiolone are infused with a peanut butter flavor. It makes them enticing to rodents.

bait attractants


On the other hand, the bait attractants of bromethalin are palatable, appealing to rodents’ taste preferences.

Factor 5: Dosage

The recommended dosages of Bromadiolone is six to seven blocks per placement. You need to take intervals of 15-30 feet between the placement. Determining the appropriate dosage for bromadiolone is more complex. Because the toxicity can be influenced by other factors as well.  

On the other hand,  Bromethalin typically requires 2 to 8 blocks per placement. You must maintain a gap of approximately 15 to 30 feet between placements. Rat population size and behavior may influence the specific dosages.

If you want to know the appropriate doses, you should seek guidance from a professional. 

Factor 6: Resistance 

Bromadiolone has no reported cases of resistance despite its active properties. On the other hand, Bromethalin is resistant to mold in humid environments. Because it is made of wax blocks designed to withstand extreme temperatures.

Factor 7: Human And Pets Toxicity

Bromadiolone is toxic for humans and highly toxic for pets. If accidentally humans or pets inhale this product, you will notice the symptoms like mucosa hemorrhage, digestive tract hemorrhage, and hematemesis. So, pet owners must be aware if their pets have consumed poison. 

Bromethalin is highly toxic for humans and pets. Nausea, vomiting, abdominal pain, and diarrhea are the most common initial effects of unintentional exposure to bromethalin in humans. 

For pets, signs to watch for include severe muscle tremors, hyperexcitability, fits, and extreme sensitivity to touch (hyperesthesia). If an animal has accidentally ingested bromethalin, immediate veterinary attention should be sought. In order to ensure timely and appropriate treatment, it is important to contact a poison control center.

Factor 8: Price

Bromadiolone is more expensive than Bromethalin. Expending $38.56 will get you 4 pounds of Bromadiolone. On the other hand, the same amount of Bromethalin will cost you $25.11. 

Factor 9: How It works

Bromethalin becomes effective after the rat consumes it and enzymes in the rat’s stomach interact with the poison. These reactions lead to the destruction of red blood cells, ultimately causing the rat’s death.

Bromadiolone takes longer to take effect due to its low water solubility. After about 20 minutes of ingestion, the rat’s body breaks down bromadiolone into a more toxic compound called Difethialone.

Difethialone, formed from bromadiolone breakdown, is even more toxic than both bromadiolone and bromethalin individually. This enhanced toxicity reduces the likelihood of bacteria surviving within the rat, making it a favorable bait choice to avoid contamination.

Bromethalin’s fast action can lead to rapid rat death, while bromadiolone takes longer to show effects. Both options can effectively control rodent populations, allowing you to choose based on your desired speed of results.

Bromethalin vs Bromadiolone: Which is Better?

In terms of effectiveness, Bromadiolone is a good choice in terms of instant results. However, it will cost some extra penny of yours.

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As an added bonus, it has a peanut butter flavor so you won’t have to worry about bad odors in your home. Alternatively, if you are not in a hurry, Bromethalin is a good budget-friendly option.

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What is the difference between Brodifacoum vs Bromadiolone?

Brodifacoum is a lethal poison and a 4-hydroxycoumarin vitamin K antagonist anticoagulant. It is known to be more potent than bromadiolone. In terms of appearance, brodifacoum presents as an off-white to fawn-colored powder. That is similar to bromadiolone, which also appears as an off-white to fawn-colored powder.

What is the difference between Bromethalin and Diphacinone?

Bromethalin is not an Anticoagulant, whereas Diphacinone is classified as a non-anticoagulant substance. Also, bromethalin is generally more effective since it begins working after a single dose. 

What rat poison is illegal?

Pesticides containing brodifacoum, bromadiolone, difethialone, or difenacoum are prohibited. It is prohibited in the “wildlife habitat” areas, which include state parks, state wildlife refuges, or state conservancies. However, there are exemptions for agricultural purposes and federal agencies.


Hopefully, you’ve got a clear idea regarding every factor of Bromadiolone vs Bromethalin.  

Bromethalin and bromadiolone both offer numerous benefits, that make it difficult to determine which is superior as a mouse killer. You should give importance to your needs and preferences while picking one.

Remember one thing regardless of which, you pick you need to remain aware since both are highly toxic.