Diphacinone vs Bromethalin (Which Is Better)

Rodents are painful to deal with. To control the rodent population, you may opt to go for rodenticides. They are a proven method to keep rats away from your property. Two main types of rodenticides are diphacinone and bromethalin.

But which is better: diphacinone vs bromethalin?

Bromethalin and Diphacinone are two distinct types of rodenticides, which are substances used to kill rodents. One key difference between these two compounds lies in their mode of action.

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Bromethalin is a neurotoxin rodenticide that acts by damaging the central nervous system of rodents. On the other hand, Diphacinone is a non-anticoagulant substance.

Diphacinone vs Bromethalin: Quick Overview

Aspect Diphacinone Bromethalin
Mode of Action Anticoagulant Neurotoxin.
Chemical Formula C23H16O3 C14H7Br3F3N3O4.
Molar Mass 352.34 g/mol 577.93 g/mol.
Mode of Action Blocks blood clotting Inhibits ATP synthesis.
Target Organism Rodents Rodents.
Mechanism of Toxicity Hemorrhaging CNS damage.
Effects Internal bleeding, weakness Paralysis, convulsions, death.

Diphacinone and bromethalin are two widely used and known rodenticides to use in your household.

What Is Diphacinone?

Diphacinone is a rodenticide that acts as an antagonist to vitamin K, resulting in anticoagulant effects.

It is commonly used to control rodent populations. Diphacinone has a longer active half-life compared to other synthetic anticoagulants like 1,3-indandione.

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Diphacinone is toxic to mammals in all its forms. Exposure to this substance, either through direct contact or oral ingestion, can lead to irregular heartbeat and serious health issues related to its impact on blood clotting, depending on the dosage.

Diphacinone is classified as a first-generation anticoagulant, which means it is less toxic compared to second-generation compounds such as warfarin.

The chemical formula of Diphacinone is C23H16O3, with a molar mass of approximately 340.37 g/mol.

Chemical Structure of Diphacinone

Source: wikipedia.org

Its IUPAC name is 2-(Diphenylacetyl)-1H-indene-1,3(2H)-dione. There are alternative chemical names for this substance, including Diphenandione, Difenacin, and Ratindan.

What Is Bromethalin?

Bromethalin is a type of rodenticide that acts as a neurotoxin, specifically targeting the central nervous system of rodents.

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Its chemical formula is C14H7Br3F3N3O4, and it has a molar mass of 577.93 g/mol. The IUPAC name for bromethalin is N-methyl-2,4-dinitro-N-(2,4,6-tribromophenyl)-6-(trifluoromethyl)aniline.

The mechanism of action of bromethalin involves its metabolism into a compound called n-desmethyl-bromethalin, which then disrupts the process of mitochondrial oxidative phosphorylation.

Chemical Structure of Bromethalin

Source: wikipedia.org

This disruption leads to a decrease in the synthesis of adenosine triphosphate (ATP), which is an important energy molecule in cells. The reduced levels of ATP inhibit the activity of the sodium/potassium ATPase enzyme, causing a buildup of cerebral spinal fluid and vacuolization of myelin.

These conditions ultimately result in damage to the central nervous system of rodents. The effects include paralysis, convulsions, and, in severe cases, death.

Note: Bromethalin is specifically designed for rodent control and should not be used in proximity to humans or other non-target animals due to its neurotoxic properties.

Difference Between Diphacinone And Bromethalin

In chemical structure, they may be a lot different. But here we will be considering its working procedure while drawing the line between the two. So, here are the detailed differences that you may want to know about:

Mechanism of Action:

    • Diphacinone: Diphacinone acts as a vitamin K antagonist, inhibiting the synthesis of blood clotting factors. It prevents the regeneration of vitamin K, leading to an inability to produce functional clotting factors and causing rodents to bleed to death.
    • Bromethalin: Bromethalin works by being metabolized into n-desmethyl-bromethalin, which disrupts mitochondrial oxidative phosphorylation. This results in a decrease in adenosine triphosphate (ATP) synthesis, leading to a subsequent buildup of cerebral spinal fluid and vacuolization of myelin. 


      • Diphacinone: Diphacinone is toxic to mammals, including humans, in all its forms. It affects blood clotting and can cause serious health issues, particularly related to hemorrhaging and bleeding disorders. However, it is generally considered less toxic than second-generation anticoagulants like warfarin.
      • Bromethalin: Bromethalin is highly toxic to rodents and mammals. It primarily affects the central nervous system, leading to paralysis, convulsions, and eventual death. It does not primarily target the blood clotting system like diphacinone.

Half-Life And Persistence:

    • Diphacinone: Diphacinone has a relatively short half-life and is eliminated from the body relatively quickly. It does not persist in the environment for an extended period.
    • Bromethalin: Bromethalin has a longer half-life compared to diphacinone. It can persist in the environment for a longer duration, which may pose a risk of secondary poisoning to non-target animals that consume poisoned rodents.

Generation Classification:

    • Diphacinone: Diphacinone is a first-generation anticoagulant rodenticide.
    • Bromethalin: Bromethalin is not classified as an anticoagulant but rather a neurotoxic rodenticide.

It is important to follow proper safety guidelines and use rodenticides responsibly to minimize risks to non-target animals and ensure effective rodent control.


Is Diphacinone Safe For Pets?

No. As it is a strong rodenticide, it will affect your pets quite a bit. So, keep your pet away from diphacinone. It can be dangerous.

Do Diphacinone And Bromethalin Affect Other Animals?

Yes, it can affect other small animals. That’s why we don’t recommend you to leave it open at places. The best would be to use it as bait for traps.

Can Diphacinone And Bromethalin Kill Roof Rats?

Yes, both rodenticides can kill roof rats. They fall victim to these rat poisons very easily.

Are Diphacinone And Bromethalin Harmful To The Environment?

Both Diphacinone and Bromethalin have the potential to harm the environment if misused or overused. Careful application and proper disposal are crucial to minimize their impact.


So, that’s it for today. Hope you know which rodenticide between diphacinone vs bromethalin will be a better choice for you. If you are still confused about it, you can contact a professional who can help you with it.

If you have any feedback, do let us know. Best of luck!